The crash happened in the southbound lanes on SR-167 and 24th Street East.
Trooper Robert Reyer said a driver was going the wrong way and crashed into another car head-on.
The wrong-way driver was taken into custody and is suspected of driving under the influence, investigators said.
Reyer said the suspected DUI driver does not have any known injuries and the other driver was taken to a local hospital for serious, non-life-threatening injuries.
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