According to the Seattle Fire Department (SFD), crews responded to the crash that happened on southbound 15th Ave., between 77th and 8th street at around 5:30 a.m.
The SFD confirmed that one person, a man in his 40s, died in the crash.
Seattle Police officers closed the southbound lanes as they investigated the scene, and crews extricated the man out of the older-model Nissan Pathfinder.
Investigators say the driver appeared to have swerved off the road, clipped a tree, completely broke a second tree in half and came to a rest, wrapped around a third tree.
Authorities say only one car was at the scene. The cause of the crash remains unclear at this time.
This is a developing story.